Most then existing HLLs were very usable in 640Kb. If you go down to 8-bits, while translators for many of these did exist the utility was rapidly diminishing. You'd essentially have system's native version of BASIC + assembler for anything practical. The rest were more of parlor tricks.
all in all, I'd really love to have or make a 1MB minimalistic shell with a tiny lisp/prolog/smalltalk