OP is asking whether Amazon offers public addresses that will respond to DNS requests for end users, such as 208.67.222.222 and 208.67.220.220 (OpenDNS).

To my knowledge, they do not - Route 53 is made for domain administrators to use as their nameservers instead of their domain registrar's.

Indeed that was my question.

On a side note, Route 53 doesn't support DNSSEC unfortunately. Might be part of the reason that Amazon.com uses Dyn and UltraDNS instead?